Annalise is a very quiet, introverted girl. When she is not having an episode, she is easily embarrassed in conversation and her lack of self esteem is evident from her body language alone. Anna has always found difficulty in making friends, never quite sure how to interact with others or handle social situations. Because of this she's very lonely. However, she's a very sweet and kind at heart and always means well even if her actions come across as awkward. She'll laugh or smile at just about any gesture though she hardly ever makes eye contact with the people she is talking to. Anna is also very submissive. She doesn't understand how to say, "no" to things she doesn't like or wants to do. People have a tendency to walk all over her and take advantage and it tears her apart on the inside and forces her into all sorts of ugly situations. She does not handle pressure very well and easily gets overwhelmed. However, what she is most noted for is her intense mood swings.

While Annalise never gets physically violent with people during an episode, she'll jump from an extremely happy and active state of mind to a suicidal mindset within seconds. Due to her illness, Anna is very touchy and sensitive. Her symptoms started to present themselves in her early childhood years. One of her worst episodes occurred on a random walk home from school. She was happily listening to her music and lightly sprinting down the street in an excited manner. Anna felt invincible and as though she could fly. In her excitement she had a difficult time returning home for she began to take out her school notebooks and rip them apart. She threw the papers into the air shouting and dancing. Eventually she found herself climbing up a tall tree and attempted to jump off a branch genuinely believing she could fly away. Fortunately, there were locals around that had reported her odd and dangerous behavior. The locals managed to prevent her from jumping but could not get her to climb down from the branch. She thought it was a very fun game. Though her demeanor quickly changed when the doctors from the local clinic appeared with an ambulance. She started to scream and became hysterical. It led to her jumping off the branch after all and it was considered attempted suicide by the clinicians. No one saw her for a few weeks and when she finally returned it was as though she were a completely different person. She then entered a depressive episode, unable to stay awake at school, grew easily agitated and often walked around as an empty shell that was no longer mentally present.

The depressive side to her condition is more unsettling than fearsome. She'll go with little to no speaking for days and will keep herself emerged in her fantasy novels. Asking her things such as, "How was your day?" is enough to make her break down in tears and become hysterical. Her mind starts to race and on occasion she'll hear voices telling her to hurt herself. Though Anna is resilient to the depressive side of her condition, never listening or giving in to the crazed thoughts but each episode always take a piece of her away. Many describe her to be a walking zombie during these times. Aside from the ups and downs, there are periods of times where Anna seems to be "normal." She's visibly more approachable and much more alert to her surroundings. During these times she'll take comfort in the small things such as eating ice cream or reading a good book. Sometimes she just enjoys going on short walks, but if she's caught out too long she gets in trouble. All in all, people find it hard to associate with Anna due to her extreme condition and instability. The few friends she does have she cherishes, even if they are not necessarily healthy people to be around. She'll do just about anything they say in fear of losing her only friends. On the other hand, occasionally Anna has extremely bad depressive episodes. When this happens she becomes very self destructive and deranged. You'll find her enclosed in a small space where she starts to scream, trash her legs and arms about, pull her own hair out and even scratch her face. However, these major depressive episodes occur very rarely. For the most part she has some sort of grip on herself throughout the mood swings.

Another odd aspect of Annalise is her constant need to be perfect. Even if she absolutely despises what she's doing, it needs to be done perfectly. This trait of hers is not particularly noticeable. Rather, it's something that sort of creeps up on Anna from the shadows and not only catches others off guard but herself too. For instance, if she's drawing lines on a page it needs to be an exact, perfectly straight horizontal/vertical line. Otherwise she'll compulsively do it over until it's fine. Her notes have to be formatted somewhat carefully and she likes to be organized. But it's more like a quirk she has that occasionally slips out. Some situations she does not care if something is not neat or a mess. In fact, she'll choose to be messy. Things only get to her when she decides to be perfect but simply can't or struggles to. You'll also notice how Anna will favor certain things like odd numbers or sets of three. Her symptoms are not really noticeable or prominent in her everyday life so it slips over both the doctor's head and her own. Once the clinic noticed, they did not make a big fuss over it seeing that it did not affect Anna's life all that much. The only concern lies with whether or not her fussing would send her off into an episode.